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Key Event Title
Immune system inflammation
Key Event Components
|abnormal acute inflammation||increased|
Key Event Overview
AOPs Including This Key Event
Key Event Description
Lymphocytes found throughout the airway and lung parenchyma are involved in the airway acute inflammation involving both innate and adaptive defenses
Epithelial cells produce TNF-α, and other cytokines to recruit inflammatory cells onto the site of inflammation.
How It Is Measured or Detected
Mice are exposed via inhalation, daily for 3 consecutive days, and subsequently lymphocyte proliferation in draining (mandibular) lymph nodes is measured.
Alternatively, cytokines can be measured with elisa.