API

Event: 1225

Key Event Title

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Immune system inflammation

Short name

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Leukocyte infiltration

Biological Context

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Level of Biological Organization
Tissue


Organ term

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Organ term
immune system


Key Event Components

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Process Object Action
inflammatory response increased
abnormal acute inflammation increased

Key Event Overview


AOPs Including This Key Event

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Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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Lymphocytes found throughout the airway and lung parenchyma are involved in the airway acute inflammation involving both innate and adaptive defenses

Epithelial cells produce TNF-α, and other cytokines to recruit inflammatory cells onto the site of inflammation.

 


How It Is Measured or Detected

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Mice are exposed via inhalation, daily for 3 consecutive days, and subsequently lymphocyte proliferation in draining (mandibular) lymph nodes is measured.

Alternatively, cytokines can be measured with elisa.


Domain of Applicability

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References

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