API

Relationship: 174

Title

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Activation, LXR leads to Activation, ChREBP

Upstream event

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Activation, LXR

Downstream event

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Activation, ChREBP

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Directness Weight of Evidence Quantitative Understanding
LXR activation leading to hepatic steatosis directly leads to Not Specified
NR1I3 (CAR) suppression leading to hepatic steatosis directly leads to Strong Strong

Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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How Does This Key Event Relationship Work

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Weight of Evidence

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Biological Plausibility

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Empirical Support for Linkage

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Uncertainties or Inconsistencies

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Quantitative Understanding of the Linkage

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Evidence Supporting Taxonomic Applicability

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References

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