API

Event: 66

Key Event Title

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Activation, ChREBP

Short name

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Activation, ChREBP

Biological Context

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Level of Biological Organization
Molecular

Cell term

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Cell term
hepatocyte


Organ term

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Key Event Components

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Process Object Action
signaling carbohydrate-responsive element-binding protein increased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
LXR Activation to Liver Steatosis KeyEvent
NR1I3 suppression to steatosis KeyEvent

Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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ChREBP is an LXR target that independently enhances the up-regulation of select lipogenic genes. The up-regulation of the ChREBP target gene is through liver-type pyruvate kinase (L-PK). Therefore, activation of LXR not only increases ChREBP mRNA via enhanced transcription but also modulates its activity [1]. In the liver, ChREBP mediates activation of several regulatory enzymes of glycolysis and lipogenesis including L-PK, acetyl CoA carboxylase (ACC), and fatty acid synthase (FAS). However, according to the study of Denechaud increase in the glucose flux in the cell is a prerequisite for ChREBP activation from T0901317 in mice [2].


How It Is Measured or Detected

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Domain of Applicability

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References

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  1. Cha & Repa 2007
  2. Denechaud et al. 2008