API

Relationship: 248

Title

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Bile accumulation, Pathological condition leads to Activation of specific nuclear receptors, Transcriptional change

Upstream event

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Bile accumulation, Pathological condition

Downstream event

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Activation of specific nuclear receptors, Transcriptional change

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Directness Weight of Evidence Quantitative Understanding
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) directly leads to Strong

Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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How Does This Key Event Relationship Work

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Weight of Evidence

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Biological Plausibility

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Empirical Support for Linkage

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Uncertainties or Inconsistencies

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Quantitative Understanding of the Linkage

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Evidence Supporting Taxonomic Applicability

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References

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