API

Relationship: 248

Title

?

Bile accumulation, Pathological condition leads to Activation of specific nuclear receptors, Transcriptional change

Upstream event

?

Bile accumulation, Pathological condition

Downstream event

?


Activation of specific nuclear receptors, Transcriptional change

Key Event Relationship Overview

?


AOPs Referencing Relationship

?

AOP Name Adjacency Weight of Evidence Quantitative Understanding
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) adjacent High

Taxonomic Applicability

?

Sex Applicability

?

Life Stage Applicability

?

Key Event Relationship Description

?


Evidence Supporting this KER

?


Biological Plausibility

?

Empirical Evidence

?

Uncertainties and Inconsistencies

?

Quantitative Understanding of the Linkage

?


Response-response Relationship

?

Time-scale

?

Known modulating factors

?

Known Feedforward/Feedback loops influencing this KER

?

Domain of Applicability

?


References

?