API

Event: 89

Key Event Title

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Synthesis, De Novo FA

Short name

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Synthesis, De Novo FA

Key Event Component

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Process Object Action
fatty acid biosynthetic process fatty acid increased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
LXR activation leading to hepatic steatosis KeyEvent

Stressors

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Level of Biological Organization

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Biological Organization
Cellular

Cell term

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Cell term
hepatocyte


Organ term

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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How This Key Event Works

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A number of pathways and a great number of enzymes like GK, L-PK, ACC, FAS and SCD-1 are involved in the de novo FA synthesis [1]. As it is already discussed above these enzymes are induced by LXR agonists (FAS, SCD1), the SREBP-1c (GK, ACC, FAS) and the ChREBP (L-PK, ACC, FAS) leading to enhancement of the de novo FA synthesis.


Metabolic-pathway-for-de-novo-FA-synthesis-and-TG-formation.png


Figure 1. Metabolic pathway for de novo FA synthesis and TG formation [1]

As proposed from Diraison et al 1997 the de novo FA synthesis contributes maximum 5% to the synthesis of FA and TG under normal conditions. Conditions associated with high rates of lipogenesis, such as low fat - high carbohydrate (LF/HC) diet, hyperglycemia, and hyperinsulinemia are associated with a shift in cellular metabolism from lipid oxidation to TG esterification, thereby increasing the availability of TGs derived from VLDL synthesis and secretion.


How It Is Measured or Detected

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Evidence Supporting Taxonomic Applicability

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References

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  1. 1.0 1.1 Postic & Girard 2008