API

Relationship: 146

Title

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Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells) leads to Peptide Oxidation

Upstream event

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Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells)

Downstream event

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Peptide Oxidation

Key Event Relationship Overview

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AOPs Referencing Relationship

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Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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Key Event Relationship Description

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Activated KCs are further an important source of ROS like superoxide (generated by NOX), but they also produce nitricoxide (NO) the counterbalance for the stimulatory effects of ROS. KCs express TNF-α, IL-1 (Interleukin-1) and MCP-1 (monocyte-chemoattractant protein-1), all being mitogens and chemoattractants for HSCs and induce the expression of platelet-derived growth factor (PDGF) receptors on HSCs cells which further enhances cell proliferation

Evidence Supporting this KER

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Biological Plausibility

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Empirical Evidence

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Uncertainties and Inconsistencies

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Quantitative Understanding of the Linkage

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Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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References

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Kolios et al., World J Gastroenterol 2006 December 14; 12(46): 7413-7420

Bataller and Brenner 2005, J.Clin. Invest. 11:209-218

Lee et al. 2011 Best Practice&Research Clinical Gastroeneterology 25, 195-206

Guo and Friedman 2007.SeminLiver Dis 27:413-426

Brenner 2009, Transactions of the America Clinical and Climatological Association, Vol 120