Relationship: 146
Title
Upstream event
Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells)Downstream event
Peptide Oxidation
Key Event Relationship Overview
AOPs Referencing Relationship
Taxonomic Applicability
Sex Applicability
Life Stage Applicability
Key Event Relationship Description
Activated KCs are further an important source of ROS like superoxide (generated by NOX), but they also produce nitricoxide (NO) the counterbalance for the stimulatory effects of ROS. KCs express TNF-α, IL-1 (Interleukin-1) and MCP-1 (monocyte-chemoattractant protein-1), all being mitogens and chemoattractants for HSCs and induce the expression of platelet-derived growth factor (PDGF) receptors on HSCs cells which further enhances cell proliferation
Evidence Supporting this KER
Quantitative Understanding of the Linkage
Domain of Applicability
References
Kolios et al., World J Gastroenterol 2006 December 14; 12(46): 7413-7420
Bataller and Brenner 2005, J.Clin. Invest. 11:209-218
Lee et al. 2011 Best Practice&Research Clinical Gastroeneterology 25, 195-206
Guo and Friedman 2007.SeminLiver Dis 27:413-426
Brenner 2009, Transactions of the America Clinical and Climatological Association, Vol 120