API

Event: 456

Key Event Title

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Suppression, Constitutive androstane receptor, NR1l3

Short name

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Suppression, Constitutive androstane receptor, NR1l3

Key Event Component

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Process Object Action
signaling nuclear receptor subfamily 1 group I member 3 decreased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
NR1I3 (CAR) suppression leading to hepatic steatosis MolecularInitiatingEvent

Stressors

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Level of Biological Organization

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Biological Organization
Molecular

Cell term

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Cell term
hepatocyte


Organ term

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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How This Key Event Works

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How It Is Measured or Detected

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Evidence Supporting Taxonomic Applicability

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Evidence for Perturbation by Stressor


Overview for Molecular Initiating Event

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References

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