API

Event: 1588

Key Event Title

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Bronchiolitis obliterans

Short name

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Bronchiolitis obliterans

Biological Context

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Level of Biological Organization
Individual



Key Event Components

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Process Object Action

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
α-diketone-induced bronchiolitis obliterans AdverseOutcome

Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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Bronchiolitis obliterans is a lung disease characterized by obstruction of the smallest airways of the lungs.

The cumulative exposure to DA correlated with the degree of airway obstruction and the incidence of BO (Kreiss et al. 2002).


How It Is Measured or Detected

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Forced expiratory volume in 1 second (FEV1)

CT scan

Thoracoscopic lung biopsy showing histological and morphological changes (human, King et al. 2011)

Other typical symptoms include: dry cough, shortness of breath and wheezing.


Domain of Applicability

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Regulatory Significance of the Adverse Outcome

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References

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Kreiss et al. 2002 (first report of DA induced BO)

Kreiss 2014 (changes in the human lung after DA exposure)