API

Relationship: 707

Title

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Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium) leads to Increase, Cytotoxicity (renal tubular cell)

Upstream event

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Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)

Downstream event

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Increase, Cytotoxicity (renal tubular cell)

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Directness Weight of Evidence Quantitative Understanding
Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) directly leads to

Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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How Does This Key Event Relationship Work

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Weight of Evidence

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Biological Plausibility

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Empirical Support for Linkage

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Uncertainties or Inconsistencies

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Quantitative Understanding of the Linkage

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Evidence Supporting Taxonomic Applicability

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References

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