API

Relationship: 159

Title

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Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307 leads to Induction, Sustained Hepatotoxicity

Upstream event

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Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307

Downstream event

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Induction, Sustained Hepatotoxicity

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Directness Weight of Evidence Quantitative Understanding
Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors directly leads to Strong

Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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How Does This Key Event Relationship Work

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Weight of Evidence

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Biological Plausibility

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Empirical Support for Linkage

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Uncertainties or Inconsistencies

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Quantitative Understanding of the Linkage

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Evidence Supporting Taxonomic Applicability

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References

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