API

Event: 50

Key Event Title

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Increase, Ca++ (intracellular)

Short name

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Increase, Ca++ (intracellular)

Key Event Component

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Process Object Action
calcium ion increased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
Calcium-mediated neuronal ROS production and energy imbalance KeyEvent

Stressors

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Level of Biological Organization

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Biological Organization
Cellular

Cell term

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Cell term
eukaryotic cell


Organ term

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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How This Key Event Works

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Decreased Ca++ ATPase activity leads to an increase in intracellular calcium [1].


How It Is Measured or Detected

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Evidence Supporting Taxonomic Applicability

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References

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  1. He, T., et al. 2009. Chronic lead exposure alters presynaptic calcium regulation and synaptic facilitation in Drosophila larvae. NeuroToxicology 30(5): 777-84.