API

Event: 1651

Key Event Title

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Cancer resistance

Short name

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Cancer resistance

Biological Context

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Level of Biological Organization
Tissue


Organ term

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Organ term
organ


Key Event Components

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Process Object Action

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
Chronic ROS leading to human gastric cancer resistance AdverseOutcome

Stressors

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Homo sapiens Homo sapiens High NCBI

Life Stages

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Life stage Evidence
All life stages High

Sex Applicability

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Term Evidence
Unspecific High

Key Event Description

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Drug resistance is involved in EMT, which is an important phenomenon exhibiting the feature similar to cancer stem cells (CSCs) (Du & Shim, 2016).

EMT is involved in metastasis and therapy resistance (Smith & Bhowmick, 2016).

Diffuse-type gastric cancer which has a poor prognosis may be related to EMT (Tanabe, Aoyagi, Yokozaki, & Sasaki, 2014).


How It Is Measured or Detected

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Cancer malignancy and EMT can be detected with biomarkers (Zeisberg & Neilson, 2009).

EMT can be detected as the increase level of the transcription factors, Zeb, Twist and Snail, related to the activation of EMT-related genes.


Domain of Applicability

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Drug resistance occurs in Homo sapiens (Du & Shim, 2016).


Regulatory Significance of the Adverse Outcome

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Cancer resistance is very important in the cancer treatment, since the cancer metastasis and recurrence are one of the main obstacles to treat cancer.


References

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Du, B., & Shim, J. S. (2016). Targeting Epithelial-Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer. Molecules, 21(7). doi:10.3390/molecules21070965

Smith, B. N., & Bhowmick, N. A. (2016). Role of EMT in Metastasis and Therapy Resistance. J Clin Med, 5(2). doi:10.3390/jcm5020017

Tanabe, S., Aoyagi, K., Yokozaki, H., & Sasaki, H. (2014). Gene expression signatures for identifying diffuse-type gastric cancer associated with epithelial-mesenchymal transition. International journal of oncology, 44(6), 1955-1970. doi:10.3892/ijo.2014.2387

Zeisberg, M., & Neilson, E. G. (2009). Biomarkers for epithelial-mesenchymal transitions. J Clin Invest, 119(6), 1429-1437. doi:10.1172/JCI36183