Event: 1651

Key Event Title


Treatment-resistant gastric cancer

Short name


Resistant gastric cancer

Biological Context


Level of Biological Organization

Organ term


Organ term

Key Event Components


Process Object Action

Key Event Overview

AOPs Including This Key Event


AOP Name Role of event in AOP
Chronic ROS leading to human treatment-resistant gastric cancer AdverseOutcome



Taxonomic Applicability


Term Scientific Term Evidence Link
Homo sapiens Homo sapiens High NCBI

Life Stages


Life stage Evidence
All life stages High

Sex Applicability


Term Evidence
Unspecific High

Key Event Description


Drug resistance is involved in EMT, which is an important phenomenon exhibiting the feature similar to cancer stem cells (CSCs) (Du & Shim, 2016).

EMT is involved in metastasis and therapy resistance (Smith & Bhowmick, 2016).

Diffuse-type gastric cancer which has a poor prognosis may be related to EMT (Tanabe, Aoyagi, Yokozaki, & Sasaki, 2014).

How It Is Measured or Detected


Cancer malignancy and EMT can be detected with biomarkers (Zeisberg & Neilson, 2009).

EMT can be detected as the increase level of the transcription factors, Zeb, Twist and Snail, related to the activation of EMT-related genes.

Domain of Applicability


Drug resistance occurs in Homo sapiens (Du & Shim, 2016).

Regulatory Significance of the Adverse Outcome


Cancer resistance is very important in the cancer treatment, since the cancer metastasis and recurrence are one of the main obstacles to treat cancer.



Du, B., & Shim, J. S. (2016). Targeting Epithelial-Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer. Molecules, 21(7). doi:10.3390/molecules21070965

Smith, B. N., & Bhowmick, N. A. (2016). Role of EMT in Metastasis and Therapy Resistance. J Clin Med, 5(2). doi:10.3390/jcm5020017

Tanabe, S., Aoyagi, K., Yokozaki, H., & Sasaki, H. (2014). Gene expression signatures for identifying diffuse-type gastric cancer associated with epithelial-mesenchymal transition. International journal of oncology, 44(6), 1955-1970. doi:10.3892/ijo.2014.2387

Zeisberg, M., & Neilson, E. G. (2009). Biomarkers for epithelial-mesenchymal transitions. J Clin Invest, 119(6), 1429-1437. doi:10.1172/JCI36183