Key Event Title
|Level of Biological Organization|
Key Event Components
Key Event Overview
AOPs Including This Key Event
|AOP Name||Role of event in AOP|
|Wnt activation leading to cancer malignancy||AdverseOutcome|
|Homo sapiens||Homo sapiens||High||NCBI|
|All life stages||High|
Key Event Description
•Cancer malignancy such as drug resistance is involved in EMT, which is an important phenomenon exhibiting the feature similar to cancer stem cells (CSCs) (Du & Shim, 2016).
•EMT is involved in metastasis and therapy resistance (Smith & Bhowmick, 2016).
•Diffuse-type gastric cancer which has a poor prognosis may be related to EMT (Tanabe, Aoyagi, Yokozaki, & Sasaki, 2014).
How It Is Measured or Detected
Cancer malignancy and EMT can be detected with biomarkers (Zeisberg & Neilson, 2009).
Domain of Applicability
Cancer malignancy such as drug resistance occurs in Homo sapiens (Du & Shim, 2016).
Regulatory Significance of the Adverse Outcome
Cancer malignancy is very important in the cancer treatment, since the cancer metastasis and recurrence are one of the main obstacles to cure cancer.
Du, B., & Shim, J. S. (2016). Targeting Epithelial-Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer. Molecules, 21(7). Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/27455225. doi:10.3390/molecules21070965
Smith, B. N., & Bhowmick, N. A. (2016). Role of EMT in Metastasis and Therapy Resistance. J Clin Med, 5(2). Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/26828526. doi:10.3390/jcm5020017
Tanabe, S., Aoyagi, K., Yokozaki, H., & Sasaki, H. (2014). Gene expression signatures for identifying diffuse-type gastric cancer associated with epithelial-mesenchymal transition. Int J Oncol, 44(6), 1955-1970. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/24728500. doi:10.3892/ijo.2014.2387
Zeisberg, M., & Neilson, E. G. (2009). Biomarkers for epithelial-mesenchymal transitions. J Clin Invest, 119(6), 1429-1437. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/19487819. doi:10.1172/JCI36183