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Relationship: 1701
Title
Activation/Proliferation, T-cells leads to Increase, Allergic Respiratory Hypersensitivity Response
Upstream event
Downstream event
Key Event Relationship Overview
AOPs Referencing Relationship
AOP Name | Adjacency | Weight of Evidence | Quantitative Understanding | Point of Contact | Author Status | OECD Status |
---|---|---|---|---|---|---|
Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response | adjacent | High | Not Specified | Jessica Ponder (send email) | Under Development: Contributions and Comments Welcome | Under Development |
Taxonomic Applicability
Sex Applicability
Sex | Evidence |
---|---|
Unspecific | High |
Life Stage Applicability
Term | Evidence |
---|---|
All life stages |
Key Event Relationship Description
In brief, once antigen has been processed and presented by DCs and Th2 cells activated (KEs 398 and 272), the differentiation and clonal expansion of Th2 cells lead to production of Th2 cytokines that induce immunoglobulin (Ig) class switching to production of antigen-specific allergic antibody (IgE) by B cells and clonal expansion of naive and memory B cell populations. (Dearman et al., 2003) These antibodies are then found throughout the body, in circulation and/or bound to Fce receptors on cells such as mast cells and basophils in tissues, including the respiratory tract. On subsequent re-exposure, antigen can crosslink IgE bound to the surface of the aforementioned cells and induce degranulation, releasing various mediators that lead to the clinical symptoms of asthma and rhinitis.
Evidence Collection Strategy
Evidence Supporting this KER
Biological Plausibility
Empirical Evidence
Type 2 innate lymphoid (GATA3+/CD3-) cells were found in bronchial biopsies of patients exhibiting TDI-induced asthma. (Blomme et al., 2020). Antihapten antibodies have been found in mice treated epicutaneously with skin and respiratory sensitizers, although they produce qualitatively different immune responses, likely reflecting the different cytokine milieus (Th1 or Th2) produced by the activated T cells in each case. While IgG1 production occurred in response to both groups of chemicals, the skin sensitizers DNCB and oxazalone preferentially drove production of IgG2a, while the respiratory sensitizers TMA and PA preferentially drove production of IgG2b. In addition, only the respiratory sensitizers were associated with an increase in serum IgE. (Dearman and Kimber, 1992, Dearman and Kimber, 1991)
Uncertainties and Inconsistencies
There is still remaining uncertainty regarding the role of IgE in chemical respiratory allergy, because specific IgE has not been demonstrated in all subjects sensitized to chemicals. (Kimber et al., 2014b, Kimber et al., 2014a, Quirce, 2014)
IgE production can occur both in the germinal centers of lymph nodes and locally in the airway mucosa, with the latter reported to be linked to nasal polyps associated with chronic rhinosinusitis and in response to inhaled protein allergens. (Baba et al., 2014, Hoddeson et al., 2010) The extent of germinal center involvement or local IgE production in respiratory sensitizers is currently unknown.
While there is considerable evidence that DCs are likely the most efficient APC for stimulating naive T cells, there is evidence that IgE at the surface of allergen-specific IgE-positive B cells and other APCs, such as alveolar macrophages, may also facilitate antigen presentation. (Zhong et al., 1997) A role for airway and alveolar epithelial cells in antigen presentation and induction and maintenance of adaptive responses is also becoming increasingly recognized. (Hasenberg et al., 2013)
Recent characterizations of the role of IL-21 in mouse models of protein allergy show that IL-21 promotes IgG1 in B cells when IL-4 is in low supply. This was supported by the finding that human ex-vivo naïve B cells from tonsils increased IgG1 but not IgE, suggesting that IgG1 may be associated with skin sensitization. (Gong et al., 2019) IL-21 was found to suppress the IgE response through IL-21R - STAT3 signaling in murine B cells. (Yang et al., 2020) However, these studies focused on murine models of allergy including dust mite and peanut, as well as a 4-hydroxy-3-nigrophenylacetyl-modified globulin, so the relevance of these mechanisms to low molecular weight chemical allergy is not clear.
Known modulating factors
Modulating Factor (MF) | MF Specification | Effect(s) on the KER | Reference(s) |
---|---|---|---|
miR-155 | Type 2 innate lymphoid cells have been shown to be dependent on miR-155 to induce airway hyperresponse and IgE elevation in mice. Using a murine miR-155 KO model, mice who did not express miR-155 did not display these effects following dermal senstization to toluene diisocyanate, in contrast to control mice. | Blomme et al., 2020) |
Quantitative Understanding of the Linkage
Response-response Relationship
Time-scale
Known Feedforward/Feedback loops influencing this KER
Domain of Applicability
References
BABA, S., KONDO, K., TOMA-HIRANO, M., KANAYA, K., SUZUKAWA, K., USHIO, M., SUZUKAWA, M., OHTA, K. & YAMASOBA, T. 2014. Local increase in IgE and class switch recombination to IgE in nasal polyps in chronic rhinosinusitis. Clin Exp Allergy, 44, 701-12.
BLOMME, E. E., PROVOOST, S., BAZZAN, E., VAN EECKHOUTTE, H. P., ROFFEL, M. P., POLLARIS, L., BONTINCK, A., BONATO, M., VANDENBROUCKE, L., VERHAMME, F., JOOS, G. F., COSIO, M. G., VANOIRBEEK, J. A. J., BRUSSELLE, G. G., SAETTA, M. & MAES, T. 2020. Innate lymphoid cells in isocyanate-induced asthma: role of microRNA-155. Eur Respir J, 56.
COLLINS, J. J., ANTEAU, S., CONNER, P. R., CASSIDY, L. D., DONEY, B., WANG, M. L., KURTH, L., CARSON, M., MOLENAAR, D., REDLICH, C. A. & STOREY, E. 2017. Incidence of Occupational Asthma and Exposure to Toluene Diisocyanate in the United States Toluene Diisocyanate Production Industry. Journal of occupational and environmental medicine, 59 Suppl 12, S22-S27.
DEARMAN, R. J. & KIMBER, I. 1991. Differential stimulation of immune function by respiratory and contact chemical allergens. Immunology, 72, 563-70.
DEARMAN, R. J. & KIMBER, I. 1992. Divergent immune responses to respiratory and contact chemical allergens: antibody elicited by phthalic anhydride and oxazolone. Clin Exp Allergy, 22, 241-50.
DEARMAN, R. J., STONE, S., CADDICK, H. T., BASKETTER, D. A. & KIMBER, I. 2003. Evaluation of protein allergenic potential in mice: dose-response analyses. Clin Exp Allergy, 33, 1586-94.
GONG, F., ZHENG, T. & ZHOU, P. 2019. T Follicular Helper Cell Subsets and the Associated Cytokine IL-21 in the Pathogenesis and Therapy of Asthma. Front Immunol, 10, 2918.
HASENBERG, M., STEGEMANN-KONISZEWSKI, S. & GUNZER, M. 2013. Cellular immune reactions in the lung. Immunol Rev, 251, 189-214.
HODDESON, E. K., PRATT, E., HARVEY, R. J. & WISE, S. K. 2010. Local and systemic IgE in the evaluation and treatment of allergy. Otolaryngol Clin North Am, 43, 503-20, viii.
KIMBER, I., DEARMAN, R. J. & BASKETTER, D. A. 2014a. Diisocyanates, occupational asthma and IgE antibody: implications for hazard characterization. J Appl Toxicol, 34, 1073-7.
KIMBER, I., DEARMAN, R. J., BASKETTER, D. A. & BOVERHOF, D. R. 2014b. Chemical respiratory allergy: reverse engineering an adverse outcome pathway. Toxicology, 318, 32-9.
QUIRCE, S. 2014. IgE antibodies in occupational asthma: are they causative or an associated phenomenon? Curr Opin Allergy Clin Immunol, 14, 100-5.
YANG, Z., WU, C. M., TARG, S. & ALLEN, C. D. C. 2020. IL-21 is a broad negative regulator of IgE class switch recombination in mouse and human B cells. J Exp Med, 217.
ZHONG, G., REIS E SOUSA, C. & GERMAIN, R. N. 1997. Antigen-unspecific B cells and lymphoid dendritic cells both show extensive surface expression of processed antigen-major histocompatibility complex class II complexes after soluble protein exposure in vivo or in vitro. J Exp Med, 186, 673-82.