This Event is licensed under the Creative Commons BY-SA license. This license allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. If you remix, adapt, or build upon the material, you must license the modified material under identical terms.
Event: 1239
Key Event Title
Altered, Gene Expression
Short name
Biological Context
Level of Biological Organization |
---|
Molecular |
Cell term
Cell term |
---|
eukaryotic cell |
Organ term
Key Event Components
Process | Object | Action |
---|---|---|
gene expression | abnormal |
Key Event Overview
AOPs Including This Key Event
AOP Name | Role of event in AOP | Point of Contact | Author Status | OECD Status |
---|---|---|---|---|
ER activation to breast cancer | KeyEvent | Molly M Morgan (send email) | Open for adoption | |
HDAC inhibition leads to neural tube defects | KeyEvent | Marvin Martens (send email) | Under Development: Contributions and Comments Welcome | |
RAR antagonism during neurodevelopment leading to impaired learning and memory | KeyEvent | Diana Lupu (send email) | Under development: Not open for comment. Do not cite |
Taxonomic Applicability
Life Stages
Sex Applicability
Key Event Description
It is well documented that alterations of histone acetylation have an impact on gene expression. Therefore if the acetylation status of the epigenetic set-up at the regulatory sequences of genes is altered, this leads to changes in gene expression.
How It Is Measured or Detected
Gene specific alterations in histone acetylation at gene regulatory seqences can be measured by chromatin immunoprecipitation (ChIPs) and gene expression analysis by RT-qPCR or whole transcriptomics (RNAseq, gene chips).