API

Event: 1239

Key Event Title

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Altered, Gene Expression

Short name

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Altered, Gene Expression

Biological Context

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Level of Biological Organization
Molecular

Cell term

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Cell term
eukaryotic cell


Organ term

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Key Event Components

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Process Object Action
gene expression abnormal

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
ER activation to breast cancer KeyEvent
HDAC inhibition leads to neural tube defects KeyEvent

Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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It is well documented that alterations of histone acetylation have an impact on gene expression. Therefore if the acetylation status of the epigenetic set-up at the regulatory sequences of genes is altered, this leads to changes in gene expression.


How It Is Measured or Detected

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Gene specific alterations in histone acetylation at gene regulatory seqences can be measured by chromatin immunoprecipitation (ChIPs) and gene expression analysis by RT-qPCR or whole transcriptomics (RNAseq, gene chips).


Domain of Applicability

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References

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