API

Relationship: 475

Title

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Inhibition, Mitochondrial fatty acid beta-oxidation leads to Accumulation, Fatty acid

Upstream event

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Inhibition, Mitochondrial fatty acid beta-oxidation

Downstream event

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Accumulation, Fatty acid

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Directness Weight of Evidence Quantitative Understanding
AhR activation leading to hepatic steatosis directly leads to Strong Strong
NR1I3 (CAR) suppression leading to hepatic steatosis directly leads to

Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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How Does This Key Event Relationship Work

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Weight of Evidence

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Biological Plausibility

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Empirical Support for Linkage

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Uncertainties or Inconsistencies

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Quantitative Understanding of the Linkage

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Evidence Supporting Taxonomic Applicability

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References

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