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N/A, Neurodegeneration leads to Encephalitis
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Adjacency||Weight of Evidence||Quantitative Understanding||Point of Contact||Author Status||OECD Status|
|Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis||adjacent||Low||Low||Anna Price (send email)||Under development: Not open for comment. Do not cite||Under Development|
Life Stage Applicability
Key Event Relationship Description
Intracerebral inoculation with CoV-OC43 in susceptible mice was found to cause acute encephalitis, with neuronal cell death by necrosis and apoptosis (de Assis et al. 2020; Jacomy H, et al. 2006).
Evidence Collection Strategy
Evidence Supporting this KER
Uncertainties and Inconsistencies
Known modulating factors
Known Feedforward/Feedback loops influencing this KER
Domain of Applicability
de Assis et al. Respiratory Syndrome Coronavirus Infections: Possible Mechanisms of Neurological Implications-A Systematic Review. Front Neurol. 2020 Aug 21;11:864.
Jacomy H, et al. Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice. Virology. (2006) 349:335–46.