Reduced, Swimming performance leads to Decrease, Population trajectory
Upstream eventReduced, Swimming performance
Decrease, Population trajectory
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Adjacency||Weight of Evidence||Quantitative Understanding|
|Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration||adjacent||High|
|teleost fish||teleost fish||High||NCBI|
Life Stage Applicability
|All life stages||High|
Key Event Relationship Description
Evidence Supporting this KER
- Fish with reduced swim performance may lack the necessary mobility to avoid predators, resulting in mortality and an eventual significant decrease to population. Reduced swim performance may also impact the fish’s ability to obtain food or prey (Voesenek et al., 2018).
- Migratory fish species with reduced swim performance would face difficulties in completing their migration path, which could result in a lack of spawning (Voesenek et al., 2018).
Uncertainties and Inconsistencies
Quantitative Understanding of the Linkage
Known modulating factors
Known Feedforward/Feedback loops influencing this KER
Domain of Applicability
Voesenek CJ, Muijres FT, van Leeuwen JL. 2018. Biomechanics of Swimming in Developing Larval Fish. Journal of Experimental Biology 221:jeb149583. doi: 10.1242/jeb.149583.