API

Relationship: 2081

Title

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Reduced, Swimming performance leads to Decrease, Population trajectory

Upstream event

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Reduced, Swimming performance

Downstream event

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Decrease, Population trajectory

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Adjacency Weight of Evidence Quantitative Understanding
Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration adjacent High

Taxonomic Applicability

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Term Scientific Term Evidence Link
teleost fish teleost fish High NCBI

Sex Applicability

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Sex Evidence
Mixed

Life Stage Applicability

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Term Evidence
All life stages High

Key Event Relationship Description

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Evidence Supporting this KER

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Biological Plausibility

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  • Fish with reduced swim performance may lack the necessary mobility to avoid predators, resulting in mortality and an eventual significant decrease to population. Reduced swim performance  may also impact the fish’s ability to obtain food or prey (Voesenek et al., 2018).
  • Migratory fish species with reduced swim performance would face difficulties in completing their migration path, which could result in a lack of spawning (Voesenek et al., 2018).

Empirical Evidence

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Uncertainties and Inconsistencies

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Quantitative Understanding of the Linkage

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Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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References

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Voesenek CJ, Muijres FT, van Leeuwen JL. 2018. Biomechanics of Swimming in Developing Larval Fish. Journal of Experimental Biology 221:jeb149583. doi: 10.1242/jeb.149583.