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Key Event Title
Increased, Oncotic Necrosis
Key Event Components
Key Event Overview
AOPs Including This Key Event
|AOP Name||Role of event in AOP||Point of Contact||Author Status||OECD Status|
|Inhibition fatty acid beta oxidation leading to nonalcoholic steatohepatisis (NASH)||KeyEvent||Lyle Burgoon (send email)||Open for adoption|
|All life stages||High|
Key Event Description
Biological state: cell death resulting from cellular swelling, as opposed to apoptosis.
Biological compartment: tissue level -- cellular swelling and death.
General role in biology: oncotic necrosis is cell death that is not planned or programmed. Oncotic necrosis typically results in inflammation.
How It Is Measured or Detected
Typically using plasma membrane permeability.
Domain of Applicability
Known to occur in most eukaryotes.