API

Event: 1131

Key Event Title

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Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin)

Short name

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Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carbo

Biological Context

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Level of Biological Organization
Molecular

Cell term

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Organ term

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Key Event Components

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Process Object Action
carboxylation reaction prothrombin decreased
carboxylation reaction coagulation factor VII (mouse) decreased
carboxylation reaction coagulation factor IX (mouse) decreased
carboxylation reaction coagulation factor X (mouse) decreased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
VKOR inhibition resulting in coagulopathy KeyEvent

Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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How It Is Measured or Detected

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Domain of Applicability

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References

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