Aopwiki

Relationship: 477

Title
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Suppression, Constitutive androstane receptor, NR1l3 leads to demethylation, PPARg promoter

Upstream event
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Suppression, Constitutive androstane receptor, NR1l3

Downstream event
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demethylation, PPARg promoter

Key Event Relationship Overview
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AOPs Referencing Relationship
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AOP Name	Adjacency	Weight of Evidence	Quantitative Understanding
NR1I3 (CAR) suppression leading to hepatic steatosis	adjacent	High	High

Taxonomic Applicability
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Sex Applicability
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Life Stage Applicability
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Key Event Relationship Description
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Evidence Supporting this KER
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Biological Plausibility
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Empirical Evidence
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Uncertainties and Inconsistencies
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Quantitative Understanding of the Linkage
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Response-response Relationship
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Time-scale
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Known modulating factors
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Known Feedforward/Feedback loops influencing this KER
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Domain of Applicability
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References
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