API

Relationship: 1247

Title

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Increase, Cell Proliferation (Epithelial Cells) leads to Increased, Ductal Hyperplasia

Upstream event

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Increase, Cell Proliferation (Epithelial Cells)

Downstream event

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Increased, Ductal Hyperplasia

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Adjacency Weight of Evidence Quantitative Understanding
Estrogen receptor activation leading to breast cancer adjacent High High
Increased DNA damage leading to increased risk of breast cancer adjacent Not Specified Not Specified
Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer adjacent Not Specified Not Specified

Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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Key Event Relationship Description

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Evidence Supporting this KER

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Biological Plausibility

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Empirical Evidence

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Uncertainties and Inconsistencies

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Quantitative Understanding of the Linkage

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Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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References

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