API

Event: 585

Key Event Title

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Decreased, Sodium conductance 1

Short name

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Decreased, Sodium conductance 1

Key Event Component

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Process Object Action
action potential decreased

Key Event Overview

AOPs Including This Key Event

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AOP Name Role of event in AOP
Sodium channel inhibition leading to reduced survival KeyEvent
sodium channel inhibition leading to increased predation KeyEvent
Sodium channel inhibition leading to congenital malformations KeyEvent
Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival KeyEvent

Stressors

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Level of Biological Organization

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Biological Organization
Cellular

Cell term

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Cell term
eukaryotic cell


Organ term

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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How This Key Event Works

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The quick rise and fall of an electrical membrane potential of a cell, known as an action potential, is either diminished or eliminated.


How It Is Measured or Detected

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Evidence Supporting Taxonomic Applicability

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Action potentials are found throughout multicellular organisms (plants, invertebrates, and vertebrates). Sponges are multicellular eukaryotes that do not transmit action potentials.


References

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