API
Event: 585
Key Event Title
Decreased, Sodium conductance 1
Short name
Decreased, Sodium conductance 1Biological Context
| Level of Biological Organization |
|---|
| Cellular |
Cell term
| Cell term |
|---|
| eukaryotic cell |
Organ term
Key Event Components
| Process | Object | Action |
|---|---|---|
| action potential | decreased |
Key Event Overview
AOPs Including This Key Event
| AOP Name | Role of event in AOP |
|---|---|
| sodium channel inhibition 1 | KeyEvent |
| sodium channel inhibition 2 | KeyEvent |
| sodium channel inhibition 3 | KeyEvent |
| ether-a-go-go (ERG) inhibition | KeyEvent |
Stressors
Taxonomic Applicability
Life Stages
Sex Applicability
Key Event Description
The quick rise and fall of an electrical membrane potential of a cell, known as an action potential, is either diminished or eliminated.
How It Is Measured or Detected
Domain of Applicability
Action potentials are found throughout multicellular organisms (plants, invertebrates, and vertebrates). Sponges are multicellular eukaryotes that do not transmit action potentials.