API XML

Aop: 95

AOP Title

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Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival

Short name:

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ether-a-go-go (ERG) inhibition

Graphical Representation

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Click to download graphical representation template

Authors

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Kellie Fay

Point of Contact

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Kellie Fay   (email point of contact)

Contributors

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  • Kellie Fay

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
Decreased, Sodium conductance 1 September 16, 2017 10:15
Reduced, swimming speed November 29, 2016 19:16
Reduced, feeding 1 November 29, 2016 19:16
Increased, predation December 03, 2016 16:37
Reduced, survival December 03, 2016 16:37
Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel December 03, 2016 16:33
Decreased, Sodium conductance 1 leads to Reduced, swimming speed December 03, 2016 16:37
Reduced, swimming speed leads to Reduced, feeding 1 December 03, 2016 16:37
Reduced, swimming speed leads to Increased, predation December 03, 2016 16:37
Reduced, feeding 1 leads to Increased, predation December 03, 2016 16:37
Increased, predation leads to Reduced, survival December 03, 2016 16:37
Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel leads to Decreased, Sodium conductance 1 December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 593 Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
2 KE 585 Decreased, Sodium conductance 1 Decreased, Sodium conductance 1
3 KE 586 Reduced, swimming speed Reduced, swimming speed
4 KE 587 Reduced, feeding 1 Reduced, feeding 1
5 KE 588 Increased, predation Increased, predation
6 AO 592 Reduced, survival Reduced, survival

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increased, predation leads to Reduced, survival adjacent High
Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel leads to Decreased, Sodium conductance 1 adjacent High
Decreased, Sodium conductance 1 leads to Reduced, swimming speed non-adjacent Low
Reduced, swimming speed leads to Reduced, feeding 1 non-adjacent
Reduced, swimming speed leads to Increased, predation non-adjacent
Reduced, feeding 1 leads to Increased, predation non-adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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This AOP is largely based on biological plausibility and a few studies in aquatic species exposed to ERG or similar channel blockers. It should be considered speculative and untested.

Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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