API

Aop: 95

AOP Title

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Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival

Short name:

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ether-a-go-go (ERG) inhibition

Authors

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Kellie Fay

Point of Contact

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Kellie Fay

Contributors

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  • Kellie Fay

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Decreased, Sodium conductance 1 September 16, 2017 10:15
Reduced, swimming speed November 29, 2016 19:16
Reduced, feeding 1 November 29, 2016 19:16
Increased, predation December 03, 2016 16:37
Reduced, survival December 03, 2016 16:37
Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel December 03, 2016 16:33
Decreased, Sodium conductance 1 leads to Reduced, swimming speed December 03, 2016 16:37
Reduced, swimming speed leads to Reduced, feeding 1 December 03, 2016 16:37
Reduced, swimming speed leads to Increased, predation December 03, 2016 16:37
Reduced, feeding 1 leads to Increased, predation December 03, 2016 16:37
Increased, predation leads to Reduced, survival December 03, 2016 16:37
Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel leads to Decreased, Sodium conductance 1 December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel

Key Events

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Title Short name
Decreased, Sodium conductance 1 Decreased, Sodium conductance 1
Reduced, swimming speed Reduced, swimming speed
Reduced, feeding 1 Reduced, feeding 1
Increased, predation Increased, predation

Adverse Outcome

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Title Short name
Reduced, survival Reduced, survival

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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This AOP is largely based on biological plausibility and a few studies in aquatic species exposed to ERG or similar channel blockers. It should be considered speculative and untested.

Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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