API

Event: 258

Key Event Title

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Activation, SCD-1

Short name

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Activation, SCD-1

Key Event Component

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Process Object Action
gene expression acyl-CoA desaturase increased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
LXR activation leading to hepatic steatosis KeyEvent

Stressors

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Level of Biological Organization

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Biological Organization
Molecular

Cell term

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Cell term
hepatocyte


Organ term

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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How This Key Event Works

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In addition to the FAS gene induction LXR activation leads to the direct induction of the stearoyl-CoA desaturase 1 (SCD1) in SREBP-1c-deficient mice [1], [2], [3]. The role of SCD-1 could be crucial for the lipogenic activity of LXRs as there are data supporting that SCD-1 deficient mice are completely protected against hypertriglyceridemia and TG accumulation in liver is decreased after treatment with T0901317 [4].


How It Is Measured or Detected

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Evidence Supporting Taxonomic Applicability

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References

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  1. Oisterveer et al. 2010
  2. Liang et al. 2002
  3. Schultz et al. 2000
  4. Chu et al. 2006