API

Event: 258

Key Event Title

?

Activation, SCD-1

Short name

?

Activation, SCD-1

Biological Context

?

Level of Biological Organization
Molecular

Cell term

?

Cell term
hepatocyte


Organ term

?


Key Event Components

?

Process Object Action
gene expression acyl-CoA desaturase increased

Key Event Overview


AOPs Including This Key Event

?

AOP Name Role of event in AOP
LXR Activation to Liver Steatosis KeyEvent

Stressors

?


Taxonomic Applicability

?


Life Stages

?


Sex Applicability

?


Key Event Description

?


In addition to the FAS gene induction LXR activation leads to the direct induction of the stearoyl-CoA desaturase 1 (SCD1) in SREBP-1c-deficient mice [1], [2], [3]. The role of SCD-1 could be crucial for the lipogenic activity of LXRs as there are data supporting that SCD-1 deficient mice are completely protected against hypertriglyceridemia and TG accumulation in liver is decreased after treatment with T0901317 [4].


How It Is Measured or Detected

?



Domain of Applicability

?



References

?


  1. Oisterveer et al. 2010
  2. Liang et al. 2002
  3. Schultz et al. 2000
  4. Chu et al. 2006