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Event: 772
Key Event Title
Increase, Hyperplasia (glandular epithelial cells of endometrium)
Short name
Biological Context
Level of Biological Organization |
---|
Cellular |
Cell term
Cell term |
---|
glandular cell of endometrium |
Organ term
Key Event Components
Process | Object | Action |
---|---|---|
endometrium hyperplasia | glandular cell of endometrium | increased |
Key Event Overview
AOPs Including This Key Event
AOP Name | Role of event in AOP | Point of Contact | Author Status | OECD Status |
---|---|---|---|---|
Dopaminergic activity- endometrial carcinoma | KeyEvent | Charles Wood (send email) | Under Development: Contributions and Comments Welcome | |
Activation of uterine estrogen receptor-alfa, endometrial adenocarcinoma | KeyEvent | Barbara Viviani (send email) | Under development: Not open for comment. Do not cite | Under Review |
Taxonomic Applicability
Life Stages
Sex Applicability
Key Event Description
Hyperplasia is an increased number of cells in an organ or tissue in response to a stimulus and is the result of growth factors or hormone triggered proliferation. Two types of hyperplasia are recognised, physiologic and pathologic hyperplasia. Physiologic hyperplasia take place when there is a need to increase functional capacity of hormone sensitive organs (e.g. endometrium during the menstrual cycle to prepare the uterus for pregnancy). Excessive or inappropriate actions of growth factors or hormones drives pathologic hyperplasia (e.g. endometrial hyperplasia due to estrogen dominance) (Robbins and Cotran, 2015).
How It Is Measured or Detected
Domain of Applicability
References
Robbins and Cotran Pathologic Basis of Disease. 9th ed. Kumar V., Abbas A.K., Aster J.C., editors. Elsevier/Saunders; 2015. Neoplasia; pp. 284-290