API

Relationship: 457

Title

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Induction, Ataxia, paralysis, or hyperactivity leads to Increased, Respiratory distress/arrest

Upstream event

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Induction, Ataxia, paralysis, or hyperactivity

Downstream event

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Increased, Respiratory distress/arrest

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Adjacency Weight of Evidence Quantitative Understanding
Acetylcholinesterase inhibition leading to acute mortality adjacent Moderate Low

Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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Key Event Relationship Description

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Muscle paralysis localized to the diaphragm can cause respiratory distress or complete respiratory failure.

Evidence Supporting this KER

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Biological Plausibility

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  • Given the role of the diaphragm in mediating contraction and expansion of the lungs in association with respiration, it is plausible that ataxia or paralysis of the diaphragm could impair breathing.

Empirical Evidence

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Not systematically evaluated.

Uncertainties and Inconsistencies

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Quantitative Understanding of the Linkage

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Not systematically evaluated.

Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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This key event is likely to be relevant only to organisms that rely on expansion and contraction of the lungs via the diaphragm for respiration.

References

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