API

Relationship: 457

Title

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Induction, Ataxia, paralysis, or hyperactivity leads to Increased, Respiratory distress/arrest

Upstream event

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Induction, Ataxia, paralysis, or hyperactivity

Downstream event

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Increased, Respiratory distress/arrest

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Directness Weight of Evidence Quantitative Understanding
Acetylcholinesterase inhibition leading to acute mortality directly leads to Moderate Weak

Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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How Does This Key Event Relationship Work

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Muscle paralysis localized to the diaphragm can cause respiratory distress or complete respiratory failure.

Weight of Evidence

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Biological Plausibility

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  • Given the role of the diaphragm in mediating contraction and expansion of the lungs in association with respiration, it is plausible that ataxia or paralysis of the diaphragm could impair breathing.

Empirical Support for Linkage

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Not systematically evaluated.

Uncertainties or Inconsistencies

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Quantitative Understanding of the Linkage

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Not systematically evaluated.

Evidence Supporting Taxonomic Applicability

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This key event is likely to be relevant only to organisms that rely on expansion and contraction of the lungs via the diaphragm for respiration.

References

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