Upstream eventOccurrence, Metaplasia of goblet cells
Increase, Mucin production
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Adjacency||Weight of Evidence||Quantitative Understanding|
|EGFR Activation Leading to Decreased Lung Function||adjacent||Low||Low|
Life Stage Applicability
Key Event Relationship Description
Chronic mucus hypersecretion is a main feature of chronic lung diseases, and the presence of goblet cell hyperplasia or goblet cell metaplasia in the lungs of chronic opbstructive pulmonary disease, asthma and cystic fibrosis patients has been inferred as cause for sustained mucus production (Rose and Voynow, 2006; Munkholm and Mortensen, 2014).
Evidence Supporting this KER
Uncertainties and Inconsistencies
Quantitative Understanding of the Linkage
Known modulating factors
Known Feedforward/Feedback loops influencing this KER
Domain of Applicability
Munkholm, M., and Mortensen, J. (2014). Mucociliary clearance: pathophysiological aspects. Clin Physiol Funct Imaging 34, 171-177.
Rose, M.C., and Voynow, J.A. (2006). Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol Rev 86, 245-278.