API

Relationship: 1313

Title

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Occurrence, Metaplasia of goblet cells leads to Increase, Mucin production

Upstream event

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Occurrence, Metaplasia of goblet cells

Downstream event

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Increase, Mucin production

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Adjacency Weight of Evidence Quantitative Understanding
EGFR Activation Leading to Decreased Lung Function adjacent Low Low

Taxonomic Applicability

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Term Scientific Term Evidence Link
human Homo sapiens Moderate NCBI

Sex Applicability

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Sex Evidence
Mixed Low

Life Stage Applicability

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Term Evidence
Adults Moderate

Key Event Relationship Description

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Chronic mucus hypersecretion is a main feature of chronic lung diseases, and the presence of goblet cell hyperplasia or goblet cell metaplasia in the lungs of chronic opbstructive pulmonary disease, asthma and cystic fibrosis patients has been inferred as cause for sustained mucus production (Rose and Voynow, 2006; Munkholm and Mortensen, 2014).

Evidence Supporting this KER

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Biological Plausibility

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Empirical Evidence

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Uncertainties and Inconsistencies

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Quantitative Understanding of the Linkage

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Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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References

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Munkholm, M., and Mortensen, J. (2014). Mucociliary clearance: pathophysiological aspects. Clin Physiol Funct Imaging 34, 171-177.

Rose, M.C., and Voynow, J.A. (2006). Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol Rev 86, 245-278.