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Alveolar collapse leads to Loss of alveolar capillary membrane integrity
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Adjacency||Weight of Evidence||Quantitative Understanding||Point of Contact||Author Status||OECD Status|
|Lung surfactant function inhibition leading to decreased lung function||adjacent||Jorid Birkelund Sørli (send email)||Open for comment. Do not cite||Under Development|
Life Stage Applicability
|All life stages||Moderate|
Key Event Relationship Description
Alveolar collapse (KE 1673) (KE upstream) results from high surface tension in the alveoli, particularly at the end of expiration (when the surface area of the alveoli are at their smallest). Alveolar collapse is difficult to measure on the individual level as collapsed alveoli may open with in breath, but then collapse again. The opening and closing of the alveoli puts stress on the alveolar-capillary membrane that is enhanced in case of additional high surface tension, resulting in loss of integrity between the blood and the air in the lungs (KE 1498) KEdownstream).