API

Relationship: 1086

Title

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Suppression, Estrogen receptor (ER) activity leads to Decrease, E2 blood concentrations at hypothalamus

Upstream event

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Suppression, Estrogen receptor (ER) activity

Downstream event

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Decrease, E2 blood concentrations at hypothalamus

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Adjacency Weight of Evidence Quantitative Understanding
Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse non-adjacent High

Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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Key Event Relationship Description

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Evidence Supporting this KER

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Biological Plausibility

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Empirical Evidence

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Uncertainties and Inconsistencies

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Quantitative Understanding of the Linkage

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Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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References

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