API

Event: 783

Key Event Title

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Increase, Cytotoxicity (tubular epithelial cells)

Short name

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Increase, Cytotoxicity (tubular epithelial cells)

Key Event Component

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Process Object Action
cell death nephron tubule epithelial cell increased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) MolecularInitiatingEvent

Stressors

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Name
Chloroform

Level of Biological Organization

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Biological Organization
Cellular

Cell term

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Cell term
nephron tubule epithelial cell


Organ term

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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How This Key Event Works

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This key event can be associated with Cyp2e1-mediated bioactivation.


How It Is Measured or Detected

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Evidence Supporting Taxonomic Applicability

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Evidence for Perturbation by Stressor


Overview for Molecular Initiating Event

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References

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