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AOP: 116
Title
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
Short name
Graphical Representation
Point of Contact
Contributors
- Charles Wood
Coaches
OECD Information Table
OECD Project # | OECD Status | Reviewer's Reports | Journal-format Article | OECD iLibrary Published Version |
---|---|---|---|---|
1.29 |
This AOP was last modified on April 29, 2023 16:02
Revision dates for related pages
Page | Revision Date/Time |
---|---|
Increase, Cytotoxicity (tubular epithelial cells) | September 16, 2017 10:16 |
Increase, Regenerative cell proliferation (tubular epithelial cells) | September 16, 2017 10:16 |
Increase, Hyperplasia (tubular epithelial cells) | September 16, 2017 10:16 |
Increase, Adenomas/carcinomas (renal tubular) | September 16, 2017 10:16 |
Increase, Cytotoxicity (tubular epithelial cells) leads to Increase, Regenerative cell proliferation (tubular epithelial cells) | December 03, 2016 16:38 |
Increase, Regenerative cell proliferation (tubular epithelial cells) leads to Increase, Hyperplasia (tubular epithelial cells) | December 03, 2016 16:38 |
Increase, Hyperplasia (tubular epithelial cells) leads to Increase, Adenomas/carcinomas (renal tubular) | December 03, 2016 16:38 |
Abstract
This putative adverse outcome pathway (AOP) outlines potential key events leading to a tumor outcome in standard carcinogenicity models. This information is based largely on modes of action described previously in cited literature sources and is intended as a resource template for AOP development and data organization. Presentation in this Wiki does not indicate EPA acceptance of a particular pathway for a given reference agent, only that the information has been proposed in some manner. In addition, this putative AOP relates to the model species indicated and does not directly address issues of human relevance.
AOP Development Strategy
Context
Strategy
Summary of the AOP
Events:
Molecular Initiating Events (MIE)
Key Events (KE)
Adverse Outcomes (AO)
Type | Event ID | Title | Short name |
---|
MIE | 783 | Increase, Cytotoxicity (tubular epithelial cells) | Increase, Cytotoxicity (tubular epithelial cells) |
KE | 710 | Increase, Regenerative cell proliferation (tubular epithelial cells) | Increase, Regenerative cell proliferation (tubular epithelial cells) |
KE | 784 | Increase, Hyperplasia (tubular epithelial cells) | Increase, Hyperplasia (tubular epithelial cells) |
AO | 713 | Increase, Adenomas/carcinomas (renal tubular) | Increase, Adenomas/carcinomas (renal tubular) |
Relationships Between Two Key Events (Including MIEs and AOs)
Title | Adjacency | Evidence | Quantitative Understanding |
---|
Network View
Prototypical Stressors
Life Stage Applicability
Taxonomic Applicability
Term | Scientific Term | Evidence | Link |
---|---|---|---|
Rattus norvegicus | Rattus norvegicus | NCBI |
Sex Applicability
Sex | Evidence |
---|---|
Male |
Overall Assessment of the AOP
Domain of Applicability
Essentiality of the Key Events
Evidence Assessment
Known Modulating Factors
Quantitative Understanding
Considerations for Potential Applications of the AOP (optional)
References
Golden, R. J., Holm, S. E., Robinson, D. E., Julkunen, P. H., & Reese, E. A. (1997). Chloroform mode of action: implications for cancer risk assessment. Regul Toxicol Pharmacol, 26(2), 142-155. doi: 10.1006/rtph.1997.1161