API

Relationship: 785

Title

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Increase, Regenerative cell proliferation (tubular epithelial cells) leads to Increase, Hyperplasia (tubular epithelial cells)

Upstream event

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Increase, Regenerative cell proliferation (tubular epithelial cells)

Downstream event

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Increase, Hyperplasia (tubular epithelial cells)

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Adjacency Weight of Evidence Quantitative Understanding
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) adjacent

Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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Key Event Relationship Description

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Sustained regenerative cell proliferation directly leads to renal tubular hyperplasia.

Evidence Supporting this KER

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Biological Plausibility

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Empirical Evidence

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Uncertainties and Inconsistencies

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Quantitative Understanding of the Linkage

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Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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References

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