API

Event: 563

Key Event Title

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Death/Failure, Colony

Short name

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Death/Failure, Colony

Key Event Component

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Process Object Action
colony collapse increased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 AdverseOutcome
Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure AdverseOutcome
Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure AdverseOutcome
Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure AdverseOutcome
Suppression of immune system contributes to impaired development and leads to colony loss/failure AdverseOutcome
Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure AdverseOutcome
Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure AdverseOutcome
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure AdverseOutcome
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste AdverseOutcome
Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure AdverseOutcome
Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 AdverseOutcome
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 AdverseOutcome
Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure AdverseOutcome
Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure AdverseOutcome
Varroa mite infestation increases virus levels leading to colony loss/failure AdverseOutcome
Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure AdverseOutcome
Weather event contributes to colony loss/failure AdverseOutcome
Weather event contributes abnormal foraging leading to colony loss/failure AdverseOutcome
Nosema infection increases energetic demands leading to colony loss/failure AdverseOutcome
Nosema infection causes abnormal role change that leads to colony loss/failure AdverseOutcome
Queen egg-laying decrease leads to colony loss/failure AdverseOutcome

Stressors

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Level of Biological Organization

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Biological Organization
Population



Taxonomic Applicability

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Life Stages

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Sex Applicability

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How This Key Event Works

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How It Is Measured or Detected

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Evidence Supporting Taxonomic Applicability

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Regulatory Examples Using This Adverse Outcome

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References

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