API

Aop: 87

AOP Title

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Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure

Short name:

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nAChR activation - colony loss 5

Authors

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Carlie A. LaLone, U.S. Environmental Protection Agency (LaLone.Carlie@epa.gov)

Point of Contact

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Carlie LaLone

Contributors

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  • Carlie LaLone

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on June 19, 2017 13:33

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Revision dates for related pages

Page Revision Date/Time
Activation, Nicotinic acetylcholine receptor September 16, 2017 10:15
N/A, Mitochondrial dysfunction 1 September 16, 2017 10:14
Impairment, Learning and memory October 26, 2017 05:38
Abnormal, Foraging activity and behavior December 03, 2016 16:37
Death/Failure, Colony December 03, 2016 16:37
Weakened, Colony December 03, 2016 16:37
Abnormal, Role change within caste December 03, 2016 16:37
Altered, Ca2+-calmodulin activated signal transduction December 03, 2016 16:37
Activation, Nicotinic acetylcholine receptor leads to N/A, Mitochondrial dysfunction 1 December 03, 2016 16:37
Impairment, Learning and memory leads to Abnormal, Foraging activity and behavior December 03, 2016 16:37
Weakened, Colony leads to Death/Failure, Colony December 03, 2016 16:38
Activation, Nicotinic acetylcholine receptor leads to Impairment, Learning and memory December 03, 2016 16:38
Abnormal, Foraging activity and behavior leads to Abnormal, Role change within caste December 03, 2016 16:38
Abnormal, Role change within caste leads to Weakened, Colony December 03, 2016 16:38
N/A, Mitochondrial dysfunction 1 leads to Altered, Ca2+-calmodulin activated signal transduction December 03, 2016 16:38
Altered, Ca2+-calmodulin activated signal transduction leads to Impairment, Learning and memory December 03, 2016 16:38

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Activation, Nicotinic acetylcholine receptor Activation, Nicotinic acetylcholine receptor

Key Events

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Title Short name
N/A, Mitochondrial dysfunction 1 N/A, Mitochondrial dysfunction 1
Impairment, Learning and memory Impairment, Learning and memory
Abnormal, Foraging activity and behavior Abnormal, Foraging activity and behavior
Weakened, Colony Weakened, Colony
Abnormal, Role change within caste Abnormal, Role change within caste
Altered, Ca2+-calmodulin activated signal transduction Altered, Ca2+-calmodulin activated signal transduction

Adverse Outcome

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Title Short name
Death/Failure, Colony Death/Failure, Colony

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Honey bee Honey bee NCBI

Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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