API XML

Aop: 90

AOP Title

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Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2

Short name:

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nAChR activation - colony loss 8

Graphical Representation

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Click to download graphical representation template

Authors

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Carlie A. LaLone, U.S. Environmental Protection Agency

Point of Contact

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Carlie LaLone   (email point of contact)

Contributors

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  • Carlie LaLone

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
Activation, Nicotinic acetylcholine receptor September 16, 2017 10:15
Impairment, Learning and memory October 26, 2017 05:38
Abnormal, Roll change within caste December 03, 2016 16:37
Reduced, Brood care December 03, 2016 16:37
impaired, Larval development December 03, 2016 16:37
Death/Failure, Colony December 03, 2016 16:37
Desensitization, Nicotinic acetylcholine receptor September 16, 2017 10:15
Decrease of neuronal network function September 16, 2017 10:14
Activation, Nicotinic acetylcholine receptor leads to Desensitization, Nicotinic acetylcholine receptor December 03, 2016 16:37
Desensitization, Nicotinic acetylcholine receptor leads to Neuronal network function, Decreased December 03, 2016 16:37
Neuronal network function, Decreased leads to Impairment, Learning and memory January 26, 2018 10:32
Impairment, Learning and memory leads to Abnormal, Roll change within caste December 03, 2016 16:37
Abnormal, Roll change within caste leads to Reduced, Brood care December 03, 2016 16:37
Reduced, Brood care leads to impaired, Larval development December 03, 2016 16:37
impaired, Larval development leads to Death/Failure, Colony December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 559 Activation, Nicotinic acetylcholine receptor Activation, Nicotinic acetylcholine receptor
2 KE 341 Impairment, Learning and memory Impairment, Learning and memory
3 KE 564 Abnormal, Roll change within caste Abnormal, Roll change within caste
4 KE 565 Reduced, Brood care Reduced, Brood care
5 KE 663 Desensitization, Nicotinic acetylcholine receptor Desensitization, Nicotinic acetylcholine receptor
6 KE 386 Decrease of neuronal network function Neuronal network function, Decreased
7 AO 566 impaired, Larval development impaired, Larval development
8 AO 563 Death/Failure, Colony Death/Failure, Colony

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Activation, Nicotinic acetylcholine receptor leads to Desensitization, Nicotinic acetylcholine receptor adjacent
Desensitization, Nicotinic acetylcholine receptor leads to Neuronal network function, Decreased adjacent
Neuronal network function, Decreased leads to Impairment, Learning and memory adjacent
Impairment, Learning and memory leads to Abnormal, Roll change within caste adjacent
Abnormal, Roll change within caste leads to Reduced, Brood care adjacent
Reduced, Brood care leads to impaired, Larval development adjacent
impaired, Larval development leads to Death/Failure, Colony adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Honey bee Honey bee NCBI

Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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