API XML

Aop: 79

AOP Title

?


Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure

Short name:

?

nAChR activation - colony loss 3

Graphical Representation

?

Click to download graphical representation template

Authors

?


Carlie A. LaLone, U.S. Environmental Protection Agency (LaLone.Carlie@epa.gov)

Point of Contact

?


Carlie LaLone   (email point of contact)

Contributors

?


  • Carlie LaLone

Status

?

Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

?

Revision dates for related pages

Page Revision Date/Time
Activation, Nicotinic acetylcholine receptor June 07, 2018 09:33
N/A, Mitochondrial dysfunction 1 March 12, 2018 11:19
Death/Failure, Colony June 07, 2018 11:15
impaired, Hive thermoregulation December 03, 2016 16:37
Weakened, Colony June 07, 2018 11:04
Activation, Nicotinic acetylcholine receptor leads to N/A, Mitochondrial dysfunction 1 December 03, 2016 16:37
N/A, Mitochondrial dysfunction 1 leads to impaired, Hive thermoregulation December 03, 2016 16:38
impaired, Hive thermoregulation leads to Weakened, Colony December 03, 2016 16:38
Weakened, Colony leads to Death/Failure, Colony December 03, 2016 16:38

Abstract

?



Background (optional)

?



Summary of the AOP

?


Events: Molecular Initiating Events (MIE)

?

Key Events (KE)

?

Adverse Outcomes (AO)

?

Sequence Type Event ID Title Short name
1 MIE 559 Activation, Nicotinic acetylcholine receptor Activation, Nicotinic acetylcholine receptor
2 KE 177 N/A, Mitochondrial dysfunction 1 N/A, Mitochondrial dysfunction 1
3 KE 568 impaired, Hive thermoregulation impaired, Hive thermoregulation
4 KE 1107 Weakened, Colony Weakened, Colony
5 AO 563 Death/Failure, Colony Death/Failure, Colony

Relationships Between Two Key Events
(Including MIEs and AOs)

?

Title Adjacency Evidence Quantitative Understanding
Activation, Nicotinic acetylcholine receptor leads to N/A, Mitochondrial dysfunction 1 adjacent
N/A, Mitochondrial dysfunction 1 leads to impaired, Hive thermoregulation adjacent
impaired, Hive thermoregulation leads to Weakened, Colony adjacent
Weakened, Colony leads to Death/Failure, Colony adjacent

Network View

?

 

Stressors

?

Life Stage Applicability

?

Taxonomic Applicability

?

Sex Applicability

?

Overall Assessment of the AOP

?



Domain of Applicability

?


Essentiality of the Key Events

?


Evidence Assessment

?


Quantitative Understanding

?


Considerations for Potential Applications of the AOP (optional)

?



References

?