API XML

Aop: 85

AOP Title

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Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure

Short name:

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Immune system - Colony loss 2

Graphical Representation

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Click to download graphical representation template

Authors

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Carlie A. LaLone, U.S. Environmental Protection Agency (LaLone.Carlie@epa.gov)

Point of Contact

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Carlie LaLone   (email point of contact)

Contributors

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  • Carlie LaLone

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
Suppression, Immune system December 03, 2016 16:37
Increased, Viral susceptibility December 03, 2016 16:37
Abnormal, Foraging activity and behavior December 03, 2016 16:37
Decrease, Number of worker bees December 03, 2016 16:37
Death/Failure, Colony December 03, 2016 16:37
Suppression, Immune system leads to Increased, Viral susceptibility December 03, 2016 16:37
Increased, Viral susceptibility leads to Abnormal, Foraging activity and behavior December 03, 2016 16:37
Abnormal, Foraging activity and behavior leads to Decrease, Number of worker bees December 03, 2016 16:37
Decrease, Number of worker bees leads to Death/Failure, Colony December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 KE 403 Suppression, Immune system Suppression, Immune system
2 KE 576 Increased, Viral susceptibility Increased, Viral susceptibility
3 KE 560 Abnormal, Foraging activity and behavior Abnormal, Foraging activity and behavior
4 AO 572 Decrease, Number of worker bees Decrease, Number of worker bees
5 AO 563 Death/Failure, Colony Death/Failure, Colony

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Suppression, Immune system leads to Increased, Viral susceptibility adjacent
Increased, Viral susceptibility leads to Abnormal, Foraging activity and behavior adjacent
Abnormal, Foraging activity and behavior leads to Decrease, Number of worker bees adjacent
Decrease, Number of worker bees leads to Death/Failure, Colony adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Honey bee Honey bee NCBI

Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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