API XML

Aop: 88

AOP Title

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Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste

Short name:

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nAChR activation - colony loss 6

Graphical Representation

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Click to download graphical representation template

Authors

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Carlie A. LaLone, U.S. Environmental Protection Agency (LaLone.Carlie@epa.gov)

Point of Contact

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Carlie LaLone   (email point of contact)

Contributors

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  • Carlie LaLone

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
Activation, Nicotinic acetylcholine receptor September 16, 2017 10:15
Impairment, Learning and memory October 26, 2017 05:38
Death/Failure, Colony December 03, 2016 16:37
Abnormal, Foraging activity and behavior December 03, 2016 16:37
Desensitization, Nicotinic acetylcholine receptor September 16, 2017 10:15
Weakened, Colony December 03, 2016 16:37
Altered, Ca2+-calmodulin activated signal transduction December 03, 2016 16:37
Activation, Nicotinic acetylcholine receptor leads to Desensitization, Nicotinic acetylcholine receptor December 03, 2016 16:37
Impairment, Learning and memory leads to Abnormal, Foraging activity and behavior December 03, 2016 16:37
Abnormal, Foraging activity and behavior leads to Weakened, Colony December 03, 2016 16:38
Weakened, Colony leads to Death/Failure, Colony December 03, 2016 16:38
Activation, Nicotinic acetylcholine receptor leads to Impairment, Learning and memory December 03, 2016 16:38
Desensitization, Nicotinic acetylcholine receptor leads to Altered, Ca2+-calmodulin activated signal transduction December 03, 2016 16:38
Altered, Ca2+-calmodulin activated signal transduction leads to Impairment, Learning and memory December 03, 2016 16:38

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 559 Activation, Nicotinic acetylcholine receptor Activation, Nicotinic acetylcholine receptor
2 KE 341 Impairment, Learning and memory Impairment, Learning and memory
3 KE 560 Abnormal, Foraging activity and behavior Abnormal, Foraging activity and behavior
4 KE 663 Desensitization, Nicotinic acetylcholine receptor Desensitization, Nicotinic acetylcholine receptor
5 KE 1107 Weakened, Colony Weakened, Colony
6 KE 1243 Altered, Ca2+-calmodulin activated signal transduction Altered, Ca2+-calmodulin activated signal transduction
7 AO 563 Death/Failure, Colony Death/Failure, Colony

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Activation, Nicotinic acetylcholine receptor leads to Desensitization, Nicotinic acetylcholine receptor adjacent
Impairment, Learning and memory leads to Abnormal, Foraging activity and behavior adjacent
Abnormal, Foraging activity and behavior leads to Weakened, Colony adjacent
Weakened, Colony leads to Death/Failure, Colony adjacent
Desensitization, Nicotinic acetylcholine receptor leads to Altered, Ca2+-calmodulin activated signal transduction adjacent
Altered, Ca2+-calmodulin activated signal transduction leads to Impairment, Learning and memory adjacent
Activation, Nicotinic acetylcholine receptor leads to Impairment, Learning and memory non-adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Honey bee Honey bee NCBI

Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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