API

Aop: 84

AOP Title

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Suppression of immune system contributes to impaired development and leads to colony loss/failure

Short name:

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Immune system - Colony loss 1

Authors

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Carlie A. LaLone, U.S. Environmental Protection Agency (LaLone.Carlie@epa.gov)

Point of Contact

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Carlie LaLone

Contributors

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  • Carlie LaLone

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Suppression, Immune system December 03, 2016 16:37
Increased, Viral susceptibility December 03, 2016 16:37
impaired, Development December 03, 2016 16:37
Decrease, Number of worker bees December 03, 2016 16:37
impaired, Hive thermoregulation December 03, 2016 16:37
Death/Failure, Colony December 03, 2016 16:37
Suppression, Immune system leads to Increased, Viral susceptibility December 03, 2016 16:37
Increased, Viral susceptibility leads to impaired, Development December 03, 2016 16:37
impaired, Development leads to Decrease, Number of worker bees December 03, 2016 16:37
Decrease, Number of worker bees leads to impaired, Hive thermoregulation December 03, 2016 16:37
impaired, Hive thermoregulation leads to Death/Failure, Colony December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Key Events

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Title Short name
Suppression, Immune system Suppression, Immune system
Increased, Viral susceptibility Increased, Viral susceptibility
impaired, Development impaired, Development

Adverse Outcome

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Title Short name
Decrease, Number of worker bees Decrease, Number of worker bees
impaired, Hive thermoregulation impaired, Hive thermoregulation
Death/Failure, Colony Death/Failure, Colony

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Honey bee Honey bee NCBI

Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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