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Aop: 80

AOP Title

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Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure

Short name:

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nAChR activation - colony loss 4

Graphical Representation

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Click to download graphical representation template

Authors

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Carlie A. LaLone, U.S. Environmental Protection Agency (LaLone.Carlie@epa.gov)

Point of Contact

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Carlie LaLone   (email point of contact)

Contributors

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  • Carlie LaLone

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
N/A, Mitochondrial dysfunction 1 September 16, 2017 10:14
Accumulation, Damaged mitochondrial DNA September 16, 2017 10:15
Accelerated, Aging December 03, 2016 16:37
Decrease, Number of worker bees December 03, 2016 16:37
impaired, Hive thermoregulation December 03, 2016 16:37
Death/Failure, Colony December 03, 2016 16:37
Overwhelmed, Mitochondrial DNA repair mechanisms September 16, 2017 10:15
Activation, Nicotinic acetylcholine receptor September 16, 2017 10:15
Activation, Nicotinic acetylcholine receptor leads to N/A, Mitochondrial dysfunction 1 December 03, 2016 16:37
N/A, Mitochondrial dysfunction 1 leads to Overwhelmed, Mitochondrial DNA repair mechanisms December 03, 2016 16:37
Overwhelmed, Mitochondrial DNA repair mechanisms leads to Accumulation, Damaged mitochondrial DNA December 03, 2016 16:37
Accumulation, Damaged mitochondrial DNA leads to Accelerated, Aging December 03, 2016 16:37
Accelerated, Aging leads to Decrease, Number of worker bees December 03, 2016 16:37
Decrease, Number of worker bees leads to impaired, Hive thermoregulation December 03, 2016 16:37
impaired, Hive thermoregulation leads to Death/Failure, Colony December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 559 Activation, Nicotinic acetylcholine receptor Activation, Nicotinic acetylcholine receptor
2 KE 177 N/A, Mitochondrial dysfunction 1 N/A, Mitochondrial dysfunction 1
3 KE 570 Accumulation, Damaged mitochondrial DNA Accumulation, Damaged mitochondrial DNA
4 KE 571 Accelerated, Aging Accelerated, Aging
5 KE 664 Overwhelmed, Mitochondrial DNA repair mechanisms Overwhelmed, Mitochondrial DNA repair mechanisms
6 AO 572 Decrease, Number of worker bees Decrease, Number of worker bees
7 AO 568 impaired, Hive thermoregulation impaired, Hive thermoregulation
8 AO 563 Death/Failure, Colony Death/Failure, Colony

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Activation, Nicotinic acetylcholine receptor leads to N/A, Mitochondrial dysfunction 1 adjacent
N/A, Mitochondrial dysfunction 1 leads to Overwhelmed, Mitochondrial DNA repair mechanisms adjacent
Overwhelmed, Mitochondrial DNA repair mechanisms leads to Accumulation, Damaged mitochondrial DNA adjacent
Accumulation, Damaged mitochondrial DNA leads to Accelerated, Aging adjacent
Accelerated, Aging leads to Decrease, Number of worker bees adjacent
Decrease, Number of worker bees leads to impaired, Hive thermoregulation adjacent
impaired, Hive thermoregulation leads to Death/Failure, Colony adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Honey bee Honey bee NCBI

Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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