API XML

Aop: 77

AOP Title

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Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1

Short name:

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nAChR activation - colony death 1

Graphical Representation

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Click to download graphical representation template

Authors

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Carlie A. LaLone, U.S. Environmental Protection Agency (LaLone.Carlie@epa.gov)

Point of Contact

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Carlie LaLone   (email point of contact)

Contributors

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  • Carlie LaLone

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
Activation, Nicotinic acetylcholine receptor September 16, 2017 10:15
N/A, Mitochondrial dysfunction 1 September 16, 2017 10:14
Impairment, Learning and memory October 26, 2017 05:38
Abnormal, Foraging activity and behavior December 03, 2016 16:37
Death/Failure, Colony December 03, 2016 16:37
Weakened, Colony December 03, 2016 16:37
Altered, Ca2+-calmodulin activated signal transduction December 03, 2016 16:37
Activation, Nicotinic acetylcholine receptor leads to N/A, Mitochondrial dysfunction 1 December 03, 2016 16:37
Impairment, Learning and memory leads to Abnormal, Foraging activity and behavior December 03, 2016 16:37
Abnormal, Foraging activity and behavior leads to Weakened, Colony December 03, 2016 16:38
Weakened, Colony leads to Death/Failure, Colony December 03, 2016 16:38
Activation, Nicotinic acetylcholine receptor leads to Impairment, Learning and memory December 03, 2016 16:38
N/A, Mitochondrial dysfunction 1 leads to Altered, Ca2+-calmodulin activated signal transduction December 03, 2016 16:38
Altered, Ca2+-calmodulin activated signal transduction leads to Impairment, Learning and memory December 03, 2016 16:38

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 559 Activation, Nicotinic acetylcholine receptor Activation, Nicotinic acetylcholine receptor
2 KE 177 N/A, Mitochondrial dysfunction 1 N/A, Mitochondrial dysfunction 1
3 KE 341 Impairment, Learning and memory Impairment, Learning and memory
4 KE 560 Abnormal, Foraging activity and behavior Abnormal, Foraging activity and behavior
5 KE 1107 Weakened, Colony Weakened, Colony
6 KE 1243 Altered, Ca2+-calmodulin activated signal transduction Altered, Ca2+-calmodulin activated signal transduction
7 AO 563 Death/Failure, Colony Death/Failure, Colony

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Activation, Nicotinic acetylcholine receptor leads to N/A, Mitochondrial dysfunction 1 adjacent
Impairment, Learning and memory leads to Abnormal, Foraging activity and behavior adjacent
Abnormal, Foraging activity and behavior leads to Weakened, Colony adjacent
Weakened, Colony leads to Death/Failure, Colony adjacent
N/A, Mitochondrial dysfunction 1 leads to Altered, Ca2+-calmodulin activated signal transduction adjacent
Altered, Ca2+-calmodulin activated signal transduction leads to Impairment, Learning and memory adjacent
Activation, Nicotinic acetylcholine receptor leads to Impairment, Learning and memory non-adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Honey bee Honey bee NCBI

Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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