API

Aop: 78

AOP Title

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Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1

Short name:

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nAChR activation - colony death/failure2

Authors

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Carlie A. LaLone, U.S Environmental Protection Agency (LaLone.Carlie@epa.gov)

Point of Contact

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Carlie LaLone

Contributors

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  • Carlie LaLone

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on February 15, 2017 19:47

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Revision dates for related pages

Page Revision Date/Time
Activation, Nicotinic acetylcholine receptor September 16, 2017 10:15
N/A, Mitochondrial dysfunction 1 September 16, 2017 10:14
Decrease of neuronal network function September 16, 2017 10:14
Impairment, Learning and memory October 26, 2017 05:38
Abnormal, Roll change within caste December 03, 2016 16:37
Reduced, Brood care December 03, 2016 16:37
impaired, Larval development December 03, 2016 16:37
Death/Failure, Colony December 03, 2016 16:37
Activation, Nicotinic acetylcholine receptor leads to N/A, Mitochondrial dysfunction 1 December 03, 2016 16:37
N/A, Mitochondrial dysfunction 1 leads to Neuronal network function, Decreased December 03, 2016 16:37
Neuronal network function, Decreased leads to Impairment, Learning and memory May 15, 2017 10:55
Impairment, Learning and memory leads to Abnormal, Roll change within caste December 03, 2016 16:37
Abnormal, Roll change within caste leads to Reduced, Brood care December 03, 2016 16:37
Reduced, Brood care leads to impaired, Larval development December 03, 2016 16:37
impaired, Larval development leads to Death/Failure, Colony December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Activation, Nicotinic acetylcholine receptor Activation, Nicotinic acetylcholine receptor

Key Events

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Title Short name
N/A, Mitochondrial dysfunction 1 N/A, Mitochondrial dysfunction 1
Decrease of neuronal network function Neuronal network function, Decreased
Impairment, Learning and memory Impairment, Learning and memory
Abnormal, Roll change within caste Abnormal, Roll change within caste
Reduced, Brood care Reduced, Brood care

Adverse Outcome

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Title Short name
impaired, Larval development impaired, Larval development
Death/Failure, Colony Death/Failure, Colony

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Honey bee Honey bee NCBI

Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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