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Agonism, Estrogen receptor leads to Increase, Vitellogenin synthesis in liver
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Adjacency||Weight of Evidence||Quantitative Understanding||Point of Contact||Author Status||OECD Status|
|Estrogen receptor agonism leading to reproductive dysfunction||adjacent||High||Tom Hutchinson (send email)||Under Development: Contributions and Comments Welcome|
Life Stage Applicability
Key Event Relationship Description
Evidence Collection Strategy
Evidence Supporting this KER
High degree of plausibility in fathead minnow, zebrafish and other cyprinid species.
Uncertainties and Inconsistencies
There are generally few inconsistencies for experimental studies using model fish species dervied from pathogen-free laboratory cultures. However, there can some uncertainties where wild fish have been used for experimental purposes.
Known modulating factors
Known Feedforward/Feedback loops influencing this KER
Domain of Applicability
Navas, J.M., Segner, H. (2006) Vitellogenin synthesis in primary cultures of fish liver cells as endpoint for in vitro screening of the (anti)estrogenic activity of chemical substances. Aquatic Toxicology 80: 1-22
Thorpe, K.L., Benstead, R., Hutchinson, T.H., Tyler, C.R. (2007). Associations between altered vitellogenin concentrations and adverse health effects in fathead minnow (Pimephales promelas). Aquatic Toxicology 85: 176-183