Upstream eventLeukocyte infiltration
Key Event Relationship Overview
AOPs Referencing Relationship
Life Stage Applicability
Key Event Relationship Description
Tissue irritation mediated by signaling molecules (cytokines, chemokines, neuropeptides) becomes established as mediators accumulate during strong or prolonged exposure to irritants. Tissue irritation lowers thresholds for nociceptive neuron stimulation and promotes pro-inflammatory signaling and irritating symptoms.