API

Relationship: 1278

Title

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Leukocyte infiltration leads to Respiratory irritability

Upstream event

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Leukocyte infiltration

Downstream event

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Respiratory irritability

Key Event Relationship Overview

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AOPs Referencing Relationship

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Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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Key Event Relationship Description

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Tissue irritation mediated by signaling molecules (cytokines, chemokines, neuropeptides) becomes established as mediators accumulate during strong or prolonged exposure to irritants. Tissue irritation lowers thresholds for nociceptive neuron stimulation and promotes pro-inflammatory signaling and irritating symptoms.

Evidence Supporting this KER

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Biological Plausibility

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Empirical Evidence

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Uncertainties and Inconsistencies

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Quantitative Understanding of the Linkage

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Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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References

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