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Relationship: 1306
Title
Increased, Motility leads to Increased, Invasion
Upstream event
Downstream event
Key Event Relationship Overview
AOPs Referencing Relationship
AOP Name | Adjacency | Weight of Evidence | Quantitative Understanding | Point of Contact | Author Status | OECD Status |
---|---|---|---|---|---|---|
Estrogen receptor activation leading to breast cancer | adjacent | Moderate | Moderate | Molly M Morgan (send email) | Open for adoption | |
Activation of the AhR leading to breast cancer | adjacent | High | Louise Benoit (send email) | Under Development: Contributions and Comments Welcome | Under Development |
Taxonomic Applicability
Term | Scientific Term | Evidence | Link |
---|---|---|---|
Homo sapiens | Homo sapiens | High | NCBI |
Sex Applicability
Sex | Evidence |
---|---|
Mixed | High |
Life Stage Applicability
Term | Evidence |
---|---|
Adults | High |
Key Event Relationship Description
The relation between cell migration and organ invasion has already been shown (KER-1306, https://aopwiki.org/relationships/1306). Since the 2 are closely linked, most articles studied both cell migration (chemo-tactic) and the capacity to invade the extra-cellular matrix. Cell invasion is indeed defined as the capacity of a cell to migrate and degrade/invade the extracellular matrix. In vitro, this process was evaluated mostly using transwell chamber with Matrigel® and the presence of matrix metalloproteinases (MMP). This effect was found in ER-positive cells, triple negative cell lines and cells overexpressing the Her2.