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Key Event Title
|Level of Biological Organization|
Key Event Components
Key Event Overview
AOPs Including This Key Event
|AOP Name||Role of event in AOP||Point of Contact||Author Status||OECD Status|
|ER activation to breast cancer||KeyEvent||Molly M Morgan (send email)||Open for adoption|
|AhR activation to breast cancer||KeyEvent||Louise Benoit (send email)||Under Development: Contributions and Comments Welcome||Under Development|
|Homo sapiens||Homo sapiens||NCBI|
Key Event Description
Cell motility is the capacity of cells to translocate onto a solid substratum. It is especially important in cancer. Indeed, cell motilityt promotes cancer agressivity. Inorder to metastise the cell must breach the basal membrane, escape from the primary tumour, migration to blood and lymphatic vessels, intravasation and extravasation and movement into distant organs (Stuleten). Cell motility is therefore essential in these steps.
How It Is Measured or Detected
Technics of measurement (Justus)
- Scratch wound
- Boyden chamber
- Organoid branching
Domain of Applicability
- Human breast cancer cell lines
Stuelten, C., Parent, C. & Montell, D. Cell motility in cancer invasion and metastasis: insights from simple model organisms. Nat Rev Cancer 18, 296–312 (2018). https://doi.org/10.1038/nrc.2018.15
Justus CR, Leffler N, Ruiz-Echevarria M, Yang LV. In vitro cell migration and invasion assays. J Vis Exp. 2014 Jun 1;(88):51046. doi: 10.3791/51046. PMID: 24962652; PMCID: PMC4186330.