API

Relationship: 154

Title

?

Decreased, HSD17B10 expression leads to Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity

Upstream event

?

Decreased, HSD17B10 expression

Downstream event

?


Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity

Key Event Relationship Overview

?


AOPs Referencing Relationship

?

AOP Name Directness Weight of Evidence Quantitative Understanding
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis directly leads to Strong

Taxonomic Applicability

?


Sex Applicability

?


Life Stage Applicability

?


How Does This Key Event Relationship Work

?


Weight of Evidence

?


Biological Plausibility

?

Empirical Support for Linkage

?

  • HSD17B10 is the gene that encodes the enzyme responsible for mitochondrial 3-hydroxyacyl-CoA dehydrogenase type-2 [1].

Uncertainties or Inconsistencies

?

Quantitative Understanding of the Linkage

?


Evidence Supporting Taxonomic Applicability

?


References

?


  1. NCBI Entrez Gene. http://www.ncbi.nlm.nih.gov/gene/3028. Accessed: 3/5/2014.