API

Relationship: 154

Title

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Decreased, HSD17B10 expression leads to Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity

Upstream event

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Decreased, HSD17B10 expression

Downstream event

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Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Adjacency Weight of Evidence Quantitative Understanding
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis adjacent High

Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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Key Event Relationship Description

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Evidence Supporting this KER

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Biological Plausibility

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Empirical Evidence

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  • HSD17B10 is the gene that encodes the enzyme responsible for mitochondrial 3-hydroxyacyl-CoA dehydrogenase type-2 [1].

Uncertainties and Inconsistencies

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Quantitative Understanding of the Linkage

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Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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References

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  1. NCBI Entrez Gene. http://www.ncbi.nlm.nih.gov/gene/3028. Accessed: 3/5/2014.