Decreased, HSD17B10 expression leads to Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity
Upstream eventDecreased, HSD17B10 expression
Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Directness||Weight of Evidence||Quantitative Understanding|
|Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis||directly leads to||Strong|
Life Stage Applicability
How Does This Key Event Relationship Work
Weight of Evidence
Empirical Support for Linkage
- HSD17B10 is the gene that encodes the enzyme responsible for mitochondrial 3-hydroxyacyl-CoA dehydrogenase type-2 .
Uncertainties or Inconsistencies
Quantitative Understanding of the Linkage
Evidence Supporting Taxonomic Applicability
- NCBI Entrez Gene. http://www.ncbi.nlm.nih.gov/gene/3028. Accessed: 3/5/2014.