API

Relationship: 517

Title

?

Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1) leads to Increased, De Novo FA synthesis

Upstream event

?

Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1)

Downstream event

?


Increased, De Novo FA synthesis

Key Event Relationship Overview

?


AOPs Referencing Relationship

?

AOP Name Directness Weight of Evidence Quantitative Understanding
NR1I3 (CAR) suppression leading to hepatic steatosis indirectly leads to Strong

Taxonomic Applicability

?


Sex Applicability

?


Life Stage Applicability

?


How Does This Key Event Relationship Work

?


Weight of Evidence

?


Biological Plausibility

?

Empirical Support for Linkage

?

Uncertainties or Inconsistencies

?

Quantitative Understanding of the Linkage

?


Evidence Supporting Taxonomic Applicability

?


References

?