Relationship: 1031
Title
Reduced, Posterior swim bladder inflation leads to Reduced, Anterior swim bladder inflation
Upstream event
Reduced, Posterior swim bladder inflationDownstream event
Reduced, Anterior swim bladder inflation
Key Event Relationship Overview
AOPs Referencing Relationship
| AOP Name | Adjacency | Weight of Evidence | Quantitative Understanding |
|---|---|---|---|
| Deiodinase 2 inhibition leading to reduced young of year survival via posterior swim bladder inflation | adjacent | ||
| Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation | adjacent |
Taxonomic Applicability
| Term | Scientific Term | Evidence | Link | |
|---|---|---|---|---|
| zebrafish | Danio rerio | NCBI | ||
| fathead minnow | Pimephales promelas | NCBI |
Sex Applicability
Life Stage Applicability
Key Event Relationship Description
Evidence Supporting this KER
Biological Plausibility
The anterior chamber is formed by evagination from the cranial end of the posterior chamber (Robertson et al., 2007, Winata et al., 2009). Therefore it is plausible to assume that the anterior chamber cannot inflate in cases where the posterior chamber is not inflated.
Quantitative Understanding of the Linkage
Domain of Applicability
References
Robertson, G.N., McGee, C.A.S., Dumbarton, T.C., Croll, R.P., Smith, F.M., 2007. Development of the swimbladder and its innervation in the zebrafish, Danio rerio. Journal of Morphology 268, 967-985.
Winata, C.L., Korzh, S., Kondrychyn, I., Zheng, W., Korzh, V., Gong, Z., 2009. Development of zebrafish swimbladder: The requirement of Hedgehog signaling in specification and organization of the three tissue layers. Developmental Biology 331, 222-236.