Upstream eventReduced, Posterior swim bladder inflation
Reduced, Anterior swim bladder inflation
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Directness||Weight of Evidence||Quantitative Understanding|
|Deiodinase 2 inhibition leading to reduced young of year survival via posterior swim bladder inflation||directly leads to|
|Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation||directly leads to|
|fathead minnow||Pimephales promelas||NCBI|
Life Stage Applicability
How Does This Key Event Relationship Work
Weight of Evidence
The anterior chamber is formed by evagination from the cranial end of the posterior chamber (Robertson et al., 2007, Winata et al., 2009). Therefore it is plausible to assume that the anterior chamber cannot inflate in cases where the posterior chamber is not inflated.
Empirical Support for Linkage
Uncertainties or Inconsistencies
Quantitative Understanding of the Linkage
Evidence Supporting Taxonomic Applicability
Robertson, G.N., McGee, C.A.S., Dumbarton, T.C., Croll, R.P., Smith, F.M., 2007. Development of the swimbladder and its innervation in the zebrafish, Danio rerio. Journal of Morphology 268, 967-985.
Winata, C.L., Korzh, S., Kondrychyn, I., Zheng, W., Korzh, V., Gong, Z., 2009. Development of zebrafish swimbladder: The requirement of Hedgehog signaling in specification and organization of the three tissue layers. Developmental Biology 331, 222-236.