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Relationship: 2806
Title
Overactivation, NMDARs leads to Loss of drebrin
Upstream event
Downstream event
Key Event Relationship Overview
AOPs Referencing Relationship
Taxonomic Applicability
Sex Applicability
Sex | Evidence |
---|---|
Unspecific | Moderate |
Life Stage Applicability
Term | Evidence |
---|---|
Adults | Moderate |
Key Event Relationship Description
Overactivationo of NMDARs induces drebrin degradation (Chimura, 2015).
Evidence Collection Strategy
Published papers (Chimura, 2015) and our own experiment.
Evidence Supporting this KER
Mouse brain extract and cell culture (Chimura, 2015)
Biological Plausibility
Empirical Evidence
Uncertainties and Inconsistencies
Known modulating factors
Quantitative Understanding of the Linkage
Response-response Relationship
Time-scale
Known Feedforward/Feedback loops influencing this KER
Domain of Applicability
References
Chimura T, Launey T, Yoshida N. “Calpain-Mediated Degradation of Drebrin by Excitotoxicity In vitro and In vivo.” PLoS One. 2015 Apr 23;10(4):e0125119. doi: 10.1371/journal.pone.0125119. eCollection 2015.